High-dose cytosine arabinoside and mitoxantrone: A highly effective regimen in refractory acute myeloid leukemia
✍ Scribed by W. Hiddemann; H. Kreutzmann; K. Straif; W. D. Ludwig; R. Donhuijsen-Ant; E. Lengfelder; Th. Büchner
- Book ID
- 112785645
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 134 KB
- Volume
- 111
- Category
- Article
- ISSN
- 1432-1335
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Forty-four patients with a diagnosis of refractory or relapsed acute myelogenous leukemia received salvage chemotherapy with high-dose cytosine arabinosine 3 g/m2 intravenously over 2 hours every 12 hours for six doses and mitoxantrone 5 mg/m2 intravenously daily for 5 days. Overall 16 patients (36%
Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete
Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance