Forty-four patients with a diagnosis of refractory or relapsed acute myelogenous leukemia received salvage chemotherapy with high-dose cytosine arabinosine 3 g/m2 intravenously over 2 hours every 12 hours for six doses and mitoxantrone 5 mg/m2 intravenously daily for 5 days. Overall 16 patients (36%
High-dose cytosine arabinoside and mitoxantrone in previously-treated acute leukemia patients
โ Scribed by C. Lejeune; N. Tubiana; J. A. Gastaut; D. Maraninchi; B. Richard; M. C. Launay; D. Sainty; G. Sebahoun; Y. Carcassonne
- Book ID
- 114791275
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 417 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0902-4441
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๐ SIMILAR VOLUMES
Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete
## BACKGROUND. Peripheral nerve toxicity has been reported but is not a commonly recognized complication of high dose cytosine arabinoside (HDAC) therapy. This study was undertaken to estimate the prevalence and describe the clinical spectrum of acute polyneuropathy associated with HDAC therapy fo