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High-dose cytosine arabinoside for acute nonlymphocytic leukemia

✍ Scribed by Dr. Guy Cantin; James K. Brennan


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
421 KB
Volume
16
Category
Article
ISSN
0361-8609

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Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance

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Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete