Treatment of patients with advanced colorectal cancer with cisplatin, 5-fluorouracil, and leucovorin
✍ Scribed by Werner Scheithauer; H. Rosen; R. Schiessel; J. Schüller; M. Karall; F. Ernst; Ch. Sebesta; G. Kornek; E. Hentschel; A. Marczell; D. Depisch
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 530 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0008-543X
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Possible prognostic variables for tumor response, time to progression (XP), and survival in 141 patients with advanced colorectal cancer treated with fluorouracil and leucovorin-based chemotherapy were analyzed, None of the variables examined for their possible influence on tumor response attained s
## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen