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5-Fluorouracil/leucovorin/interferon alpha-2a in patients with advanced colorectal cancer

โœ Scribed by Peter B. Vermeulen; Luc Y. Dirix; Gino Pelgrims; Allan T. van Oosterom; Nanno H. Mulder


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
314 KB
Volume
76
Category
Article
ISSN
0008-543X

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## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen

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## Background: Colorectal carcinoma is the third leading cause of cancer-related death. the primary treatment for patients with metastatic colorectal carcinoma is systemic chemotherapy with 5-fluorouracil (5-fu) and leucovorin (lv), a biomodulator of 5-fu that has been shown to enhance its activity