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Bimonthly high dose leucovorin and 5-fluorouracil 48-hour infusion with interferon-alpha-2a in patients with advanced colorectal carcinoma

✍ Scribed by Christophe Tournigand; Christophe Louvet; Aimery de Gramont; Elisabeth Lucchi; Jean-François Seitz; Frédéric Mal; Eric Raymond; Jean Cady; Elisabeth Carola; Marcel Krulik; for the Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD)

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
88 KB
Volume
79
Category
Article
ISSN
0008-543X

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✦ Synopsis

disease progression. IFN was administered subcutaneously three times weekly at for the Groupe d'Etude et de a dose of 3 MU (body surface area [BSA] õ 1.75 m 2 ) or 4.5 MU (BSA ¢ 1.75 m 2 ). Recherche sur les Cancers de RESULTS. World Health Organization toxicity Grade 3-4 occurred in 21 patients l'Ovaire et Digestifs (GERCOD)

(42%): diarrhea in 6%, mucositis in 12%, neutropenia in 30%, and alopecia in 8%.

The overall response rate was 44%; 1 patient had a complete response (2%), 21 had

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A simplified regimen of weekly high dose 5-fluorouracil and leucovorin as a 24-hour infusion in patients with advanced colorectal carcinoma
✍ Tsai-Shen Yang; Kuan-Cheng Hsu; Jy-Ming Chiang; Reiping Tang; Jinn-Shium Chen; C 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB 👁 1 views

## BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly

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## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen