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Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma

✍ Scribed by Karine Beerblock; Yves Rinaldi; Thierry André; Christophe Louvet; Eric Raymond; Christophe Tournigand; Elisabeth Carola; Roger Favre; Aimery de Gramont; Marcel Krulik; for the Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD)

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
86 KB
Volume
79
Category
Article
ISSN
0008-543X

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✦ Synopsis

with low dose LV. Based on these reports, a first-line Phase II study was performed in 101 patients with advanced colorectal carcinoma who were given a bimonthly

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## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen