Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer
Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma
β Scribed by Neal J. Meropol; Donna Niedzwiecki; Donna Hollis; Richard L. Schilsky; Robert J. Mayer; the Cancer; Leukemia Group B
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 107 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. The biochemical modulation of 5-fluorouracil (5-FU) by leucovorin (Lv) has demonstrated significantly increased response rates in comparison with the use of 5-FU alone in patients with advanced colorectal carcinoma. However, the higher response rate of LV/5-FU may occur at the expen
## Background: Colorectal carcinoma is the third leading cause of cancer-related death. the primary treatment for patients with metastatic colorectal carcinoma is systemic chemotherapy with 5-fluorouracil (5-fu) and leucovorin (lv), a biomodulator of 5-fu that has been shown to enhance its activity
Conducted as a collaborative trial of North Central Cancer Treatment Group and Mayo Clinic.