Treatment of advanced colorectal cancer with a combination of 5-fluorouracil and methyl-CCNU
β Scribed by Fischetti, Michael R. ;Carey, Robert W. ;Weitzman, Sigmund A. ;Kaufman, Sheldon ;Kelley, Rita M. ;Sohier, W. D.
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 146 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0098-1532
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## Abstract Consecutive studies were undertaken in advanced colorectal adenocarcinoma, comparing two different schedules of the combination methylβCCNU, 6βthioguanine, and 5βfluorouracil in 89 patients. The two schedules exhibited similar efficacies, with a combined complete and partial remission r
The combination of Ftorafur (NSC-148958) and methyl-CCNU (NSC-95441) was evaluated in 36 patients with advanced colorectal cancer. The principle toxicities encountered were myelosuppression, gastrointestinal, and neurological. There were no complete responses and only 5/34 (14.7%) patients achieved