✦ LIBER ✦

Phase I-II study of ftorafur and methyl-ccnu in advanced colorectal cancer

✍ Scribed by Robert J. Belt; Ronald Stephens

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 316 KB
Volume: 44
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197909)44:3<869::aid-cncr2820440312>3.0.co;2-f

No coin nor oath required. For personal study only.

✦ Synopsis

The combination of Ftorafur (NSC-148958) and methyl-CCNU (NSC-95441) was evaluated in 36 patients with advanced colorectal cancer. The principle toxicities encountered were myelosuppression, gastrointestinal, and neurological. There were no complete responses and only 5/34 (14.7%) patients achieved a partial response. Methyl-CCNU and Ftorafur does not appear to be an effective combination in advanced adenocarcinoma of the colon and rectum.

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