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Treatment of advanced colorectal cancer with high-dose intensity folinic acid and 5-fluorouracil plus supportive care

✍ Scribed by R. Petrioli; M. Lorenzi; A. Aquino; S. Marsili; B. Frediani; V. Palazzuoli; G. Marzocca; G. Botta; F. Tani; A. De Martino; W. Testi; C. Setacci; F. Salvestrini; D. De Sando; S. Bovenga; L. Mariani; S. Mancini; G. Tanzini; S. Armenio; E. Marinello; G. Francini

Book ID
116166574
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
503 KB
Volume
31
Category
Article
ISSN
0959-8049

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Randomized phase III Study of 5-fluorour
Randomized phase III Study of 5-fluorouracil plus high dose folinic acid versus 5-fluorouracil plus folinic acid plus methyl-lomustine for patients with advanced colorectal cancer
✍ Dennie V. Jones; Roger J. Winn; Barry W. Brown; Lawrence B. Levy; Reginald P. Pu πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 501 KB

Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized