Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized
High dose folinic acid and 5-fluorouracil bolus and continuous infusion for patients with advanced colorectal cancer
✍ Scribed by Yves H. Bécouarn; René C. Brunet; Marie-Laurence P. Rouhier; Emmanuel J. Bussières; Antoine R. Avril; Pierre M. Richaud; Jean-Marie A. Dilhuydy
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 530 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0008-543X
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Ninety-one patients with metastatic colorectal cancer were treated with continuous ambulatory 5-fluorouracil(5FU) infusion 250-300 mg/m2/day through a chronic indwelling central venous catheter. Twenty-six of the 91 patients (29%) had received previous bolus 5FU. Fifty-eight of the 91 patients (64%)
Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer