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Folinic acid plus high-dose 5-fluorouracil with allopurinol protection in the treatment of advanced colorectal carcinoma

✍ Scribed by Tsavaris, N.; Bacoyannis, Ch.; Milonakis, N.; Sarafidou, M.; Zamanis, N.; Magoulas, D.; Kosmidis, P.


Book ID
122470828
Publisher
Elsevier Science
Year
1990
Weight
373 KB
Volume
26
Category
Article
ISSN
0277-5379

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Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized