Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase
β Scribed by Hideki Fujino; Tsuyoshi Saito; Shin-ichiro Ogawa; Junji Kojima
- Book ID
- 111770390
- Publisher
- Pharmaceutical Press
- Year
- 2005
- Tongue
- English
- Weight
- 150 KB
- Volume
- 57
- Category
- Article
- ISSN
- 2042-7158
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## Abstract A new synthetic method for the preparation of pitavastatin is described. The approach circumvents various synthetic problems associated with the buildup of the 3,5βdihydroxyβC~7~ acid side chain of HMGβCoA reductase inhibitors (statins). The use of the C~6~βamide derivative **5** instea
On p. 1074, in Scheme 3, the correct formula of NK-104 should be as follows: 2) On p. 1077, line 16 should read as follows: (390 ml) was cooled to Γ 788, and 1.6m BuLi in hexane (374.4 g, 881 mmol) was added under 3) On p. 1078, line 15 should read as follows: As HPLC revealed the presence of mor