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Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2

โœ Scribed by U.Kristina Walle; Alema Galijatovic; Thomas Walle


Book ID
113994472
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
455 KB
Volume
58
Category
Article
ISSN
0006-2952

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi