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Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2

โœ Scribed by Hiroaki Yamaguchi; Ikuko Yano; Hideyuki Saito; Ken-ichi Inui

Book ID
114014377
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
170 KB
Volume
431
Category
Article
ISSN
0014-2999

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Transport of levovirin prodrugs in the h
Transport of levovirin prodrugs in the human intestinal Caco-2 cell line
โœ Fujun Li; Lei Hong; Cheng-I Mau; Rebecca Chan; Than Hendricks; Chuck Dvorak; Cal ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 142 KB ๐Ÿ‘ 1 views

The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi