𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts

✍ Scribed by Daniel Trueba; Michael Phelan; John Nelson; Fred Beck; Brian S. Pecha; R. James Brown; Harold E. Varmus; Don Ganem

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
577 KB
Volume
5
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

The infectivity and host range of ground squirrel hepatitis virus (GSHV) have been further examined by animal inoculation experiments. Although carrier squirrel sera usually harbor log to 10" virions per ml as determined by physical measurements, titration of one such serum revealed that squirrel infectivity was lost following dilution of the sample over 1O8-fold. Infectivity is markedly reduced by NP40 pretreatment of infected serum. GSHV infection cannot be readily transmitted to several related ground squirrel species, but chipmunks can be experimentally infected by GSHV virions or by cloned GSHV DNA, and the resulting infection closely resembles that seen in the normal host.

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