✦ LIBER ✦

An experimental transmission of woodchuck hepatitis virus to young chinese marmots

✍ Scribed by Jin Zhihong; Zhao Guolong; Xiong Shisong; Kou Pingyuan; Ma Lili; Chen Hongtao; Qi Jianying; Ba Qiuju; Mai Kai

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 341 KB
Volume: 8
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840080230

No coin nor oath required. For personal study only.

✦ Synopsis

Fourteen young Chinese marmots (Marmota bobak sibirica Radde) were randomly allocated to two groups of seven each. They were injected intrahepatically with a standard woodchuck hepatitis virus challenge pool or a negative pool, prepared from sera of woodchucks with and without woodchuck hepatitis virus infection, respectively. Marmot No. 2 in the experimental group experienced an episode of seroconversion from woodchuck hepatitis surface antigen to anti-woodchuck hepatitis antibody. Woodchuck hepatitis virus DNA was detected, and woodchuck hepatitis surface antigen particles of both spherical and filamentous forms and intact woodchuck hepatitis virus virions were found in its serum. By contrast, none of the control group animals (receiving the negative pool) produced any marker of woodchuck hepatitis virus. This suggests that young Chinese marmots can get woodchuck hepatitis virus infection.

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