𝔖 Bobbio Scriptorium
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Mother to infant transmission of hepatitis C virus infection

✍ Scribed by Dr. R. Wejstål; S. Hermodsson; S. Iwarson; G. Norkrans

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
289 KB
Volume
30
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Eight women with chronic hepatitis C virus (HCV) infection during pregnancy gave birth to 11 children. Five of these children had elevated ALT, but only two had increased levels in more than one sample. All children tested before 6 months of age were positive for anti‐HCV at most up to 7 months of age and then became negative. One child with a maximum ALT level of 8.4 μkat/I however, regained anti‐HCV positivity at 12 months of age, and a liver biopsy at 21 months of age showed resolving hepatitis. Passively acquired HCV antibodies are obviously found in newborns of anti‐HCV‐positive mothers with chronic hepatitis. In 1 of 11 children, active anti‐HCV production and concomitant liver disease suggested mother to infant transmission of hepatitis C virus infection.

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