✦ LIBER ✦

Translocations involving 9p and/or 12p in acute lymphoblastic leukemia

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 424 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050314

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✦ Synopsis

Fifteen cases of acute lymphoblastic leukemia (ALL) with translocations involving 9p and/or I2p are described. Four children, three males and one female, age range 1-8 yrs. had translocations involving 9p but not I2p. O f these, three had B-lineage ALL and one had biphenotypic T-ALL/acute myeloid leukemia. Six patients, three males and three females, age range I 4 9 yrs, had translocations involving 12p but not 9p. Five had B-lineage ALL and one had T-ALL. One patient had dic(7;12)(pl I;pl I), confirming that this previously reported translocation is nonrandom in ALL. One patient had t(2; I2)(q I4;p 13). and it is suggested that this may also be a new nonrandom abnormality. Five patients, four males and one female, age range I 1-2 I yrs, had common ALL and dic(9; 12). The dic(9; 12) appears to confer a better prognosis than do other translocations involving 9p or 12p. Genes Chrorn Cancer 5: 255-259 (1992). 0 1992 WiIey-Liss. Inc.

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