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Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood

✍ Scribed by Francesca Novara; Silvana Beri; Maria Ester Bernardo; Riccardo Bellazzi; Alberto Malovini; Roberto Ciccone; Angela Maria Cometa; Franco Locatelli; Roberto Giorda; Orsetta Zuffardi


Publisher
Springer
Year
2009
Tongue
English
Weight
593 KB
Volume
126
Category
Article
ISSN
0340-6717

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Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho

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## Abstract Acute lymphoblastic leukemia is the most common malignancy in childhood. High‐resolution allelotyping performed in our laboratory showed new chromosomal sites of nonrandom deletions. We have focused our work on 8q12 deletions, which we have found in about 4% of patients (eight of 205 in

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