Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho
Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood
β Scribed by Francesca Novara; Silvana Beri; Maria Ester Bernardo; Riccardo Bellazzi; Alberto Malovini; Roberto Ciccone; Angela Maria Cometa; Franco Locatelli; Roberto Giorda; Orsetta Zuffardi
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 593 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0340-6717
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## Abstract Acute lymphoblastic leukemia is the most common malignancy in childhood. Highβresolution allelotyping performed in our laboratory showed new chromosomal sites of nonrandom deletions. We have focused our work on 8q12 deletions, which we have found in about 4% of patients (eight of 205 in
Background. The prevalence, in unselected patients with acute lymphoblastic leukaemia (ALL), of clonal rearrangements suitable for minimal residual disease (MRD) studies has not been formally investigated. Procedure. This was a prospective, demographic study of the frequency of molecular markers of