✦ LIBER ✦

t(10;11)(p13–14;q14–21): A New Recurrent Translocation in T-Cell Acute Lymphoblastic Leukemias

✍ Scribed by Groupe Français de Cytogénétique Hématologique (GFCH)

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 412 KB
Volume: 3
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870030602

No coin nor oath required. For personal study only.

✦ Synopsis

A workshop held by the "Groupe Frangais de Cytogenetique Hematologique" has identified a t ( I 0 I I)(p I 3-1 4;q 14-2 I) in four acute lyrnphoblastic leukemias of T-cell lineage. The immunophenotypes were consistent with immature thymocytes. This translocation is therefore a new candidate for a recurrent translocation in early T-cell leukemia. A similar translocation has been reported as a rare change in early pre-B lymphoid leukemias and also in myeloid leukemias. It is not known whether the similar cytogenetic changes involve different molecular breakpoints or whether the same rearrangement affects a multipotential stem cell capable of lymphoid and myeloid differentiation.

📜 SIMILAR VOLUMES

t(14;19)(q32;q13): A recurrent transloca

t(14;19)(q32;q13): A recurrent translocation in B-cell precursor acute lymphoblastic leukemia

✍ Hazel M. Robinson; Kerry E. Taylor; G. Reza Jalali; Kan Luk Cheung; Christine J. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 746 KB

The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute

Hemophagocytic syndrome complicating T-c

Hemophagocytic syndrome complicating T-cell acute lymphoblastic leukemia with a novel t(11;14)(p15;q11) chromosome translocation

✍ Nobuko Takasaki; Yasuhiko Kaneko; Nobuo Maseki; Masaharu Sakurai; Kayako Shimamu 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 753 KB

A complex genetic rearrangement in a t(1

A complex genetic rearrangement in a t(10;14)(q24;q11) associated with T-cell acute lymphoblastic leukemia

✍ James K. Park; Michelle M. Le Beau; Janet D. Rowley; Manuel O. Diaz; Thomas B. S 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

The t( 1014)(q24;ql I) is observed in the leukemia cells of 5-10% of cases of T-cell acute lymphoblastic leukemia (T-ALL). Recently, molecular analyses of a number of these translocations revealed simple reciprocal translocations between the T-cell receptor delta chain gene (TCRD) and a region of IO

Hypereosinophilic syndrome in acute lymp

Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)]

✍ Tono-oka, Tatsuhito ;Sato, Yoshiko ;Matsumoto, Takahide ;Ueno, Norihiro ;Ohkawa, 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 376 KB

Molecular analysis of a t(11;14)(q23;q11

Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia

✍ Robert C. Burnett; Rafael Espinosa III; Thomas B. Shows; Roger L. Eddy; Michelle 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 764 KB

Ip;&-3qChromosome I I, band q23, is the frequent site of recurring cytogenetic rearrangements in human leukemia. We have cloned and sequenced the breakpoint junctions from a patient who had null-cell acute lymphoblastic leukemia (ALL) with a t( I 1;14)(q23;ql I). The chromosome 14 breakpoints occurr

Concurrent presence of inv(14)(q11q32) a

Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in Pre-B Acute Lymphoblastic leukemia

✍ David S. Chervinsky; Mauro Grossi; Surabhi Kakati; Annemarie W. Block; Peter D. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 744 KB

The inv( I4)(q I lq32) is a non-random chromosomal aberration which has been associated with a variety of T-cell malignancies. W e have studied a case of inv( I4)(q I I q32) that is unique in several respects. First, the inversion, which is expressed at the rnRNA level, occurred in the context of a