𝔖 Bobbio Scriptorium
✦   LIBER   ✦

t(14;19)(q32;q13): A recurrent translocation in B-cell precursor acute lymphoblastic leukemia

✍ Scribed by Hazel M. Robinson; Kerry E. Taylor; G. Reza Jalali; Kan Luk Cheung; Christine J. Harrison; Anthony V. Moorman

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
746 KB
Volume
39
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus-specific probes confirmed the involvement of the IGH@ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)-positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia.

πŸ“œ SIMILAR VOLUMES

t(10;11)(p13–14;q14–21): A New Recurrent
t(10;11)(p13–14;q14–21): A New Recurrent Translocation in T-Cell Acute Lymphoblastic Leukemias
✍ Groupe FranΓ§ais de CytogΓ©nΓ©tique HΓ©matologique (GFCH) πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 412 KB

A workshop held by the "Groupe Frangais de Cytogenetique Hematologique" has identified a t ( I 0 I I)(p I 3-1 4;q 14-2 I) in four acute lyrnphoblastic leukemias of T-cell lineage. The immunophenotypes were consistent with immature thymocytes. This translocation is therefore a new candidate for a rec

Concurrent presence of inv(14)(q11q32) a
Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in Pre-B Acute Lymphoblastic leukemia
✍ David S. Chervinsky; Mauro Grossi; Surabhi Kakati; Annemarie W. Block; Peter D. πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 744 KB

The inv( I4)(q I lq32) is a non-random chromosomal aberration which has been associated with a variety of T-cell malignancies. W e have studied a case of inv( I4)(q I I q32) that is unique in several respects. First, the inversion, which is expressed at the rnRNA level, occurred in the context of a

The B cell antigen receptor in atypical
The B cell antigen receptor in atypical chronic lymphocytic leukemia with t(14;19)(q32;q13) demonstrates remarkable stereotypy
✍ Carmen D. Schweighofer; Yang O. Huh; Rajyalakshmi Luthra; Rachel L. Sargent; Rhe πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 356 KB

## Abstract The t(14;19)(q32;q13) is a recurrent chromosomal translocation reported in a variety of B‐cell leukemias and lymphomas, including chronic lymphocytic leukemia (CLL). CLL cases associated with t(14;19) often have atypical morphologic and immunophenotypic features and unmutated immunoglob

A complex genetic rearrangement in a t(1
A complex genetic rearrangement in a t(10;14)(q24;q11) associated with T-cell acute lymphoblastic leukemia
✍ James K. Park; Michelle M. Le Beau; Janet D. Rowley; Manuel O. Diaz; Thomas B. S πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 823 KB

The t( 1014)(q24;ql I) is observed in the leukemia cells of 5-10% of cases of T-cell acute lymphoblastic leukemia (T-ALL). Recently, molecular analyses of a number of these translocations revealed simple reciprocal translocations between the T-cell receptor delta chain gene (TCRD) and a region of IO