Translocations involving 12p in acute myeloid leukemia: Association with prior myelodysplasia and exposure to mutagenic agents

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 277 KB
• Volume: 5
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870050313

✦ Synopsis

Six cases of acute myeloid leukemia (AML) with translocations involving I2p are described. The patients were one child age 7 yrs and five adults with an age range of 20-66 yrs (median 46 yrs). In t w o patients AML followed treatment for acute lymphoblastic leukemia (ALL), in one case after I I years disease-free survival. O f the remaining four patients, two had been occupationally exposed to possible mutagens and three had a previous myelodysplastic phase. Two patients achieved complete remission; survival for the six cases was between I and 24 months (median 6.5 months). The breakpoints in I2p occurred in p I I, p 12, and p 13, indicating that several sites are important in these rearrangements, and it is suggested that t( 12; I7)(p I I ;q I 1) is a new nonrandom abnormality in AML.