Translocational Inefficiency of Intracellular Proteins in Senescence of Human Diploid Fibroblasts
β Scribed by In Kyoung Lim; Kwang Won Hong; In Hae Kwak; Gyesoon Yoon; Sang Chul Park
- Book ID
- 111397121
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 996 KB
- Volume
- 928
- Category
- Article
- ISSN
- 0890-6564
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## Abstract Two predictions of the error/mutation hypothesis of cellular sensecence (Orgel, '73) namely, (a) exponential accumulation of somatic mutations during the replicative lifespan and (b) shortening of culture lifespan upon treatment with mutagens have been examined experimentally in a strai