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UVB-induced premature senescence of human diploid skin fibroblasts

✍ Scribed by Florence Chainiaux; Joao-Pedro Magalhaes; François Eliaers; José Remacle; Olivier Toussaint

Book ID
117755830
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
305 KB
Volume
34
Category
Article
ISSN
1357-2725

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✍ O Toussaint; E.E Medrano; T von Zglinicki 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 210 KB

Replicative senescence of human diploid fibroblasts (HDFs) or melanocytes is caused by the exhaustion of their proliferative potential. Stress-induced premature senescence (SIPS) occurs after many different sublethal stresses including H 2 O 2 , hyperoxia, or tert-butylhydroperoxide. Cells in replic