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Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

✍ Scribed by O Toussaint; E.E Medrano; T von Zglinicki


Book ID
114253488
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
210 KB
Volume
35
Category
Article
ISSN
0531-5565

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Cellular and molecular mechanisms of str
✍ O Toussaint; E.E Medrano; T von Zglinicki πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 210 KB

Replicative senescence of human diploid fibroblasts (HDFs) or melanocytes is caused by the exhaustion of their proliferative potential. Stress-induced premature senescence (SIPS) occurs after many different sublethal stresses including H 2 O 2 , hyperoxia, or tert-butylhydroperoxide. Cells in replic