Cellular and molecular mechanisms of str
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O Toussaint; E.E Medrano; T von Zglinicki
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Article
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2000
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Elsevier Science
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English
β 210 KB
Replicative senescence of human diploid fibroblasts (HDFs) or melanocytes is caused by the exhaustion of their proliferative potential. Stress-induced premature senescence (SIPS) occurs after many different sublethal stresses including H 2 O 2 , hyperoxia, or tert-butylhydroperoxide. Cells in replic