✦ LIBER ✦

Translocation t(8;13)(p11;q11-12) in stem cell leukemia/lymphoma of t-cell and myeloid lineages

✍ Scribed by Rizwan Naeem; Samuel Singer; Jonathan A. Fletcher

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 303 KB
Volume: 12
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870120210

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✦ Synopsis

An unusual hematologic neoplasia has been described recently in which the predominant clinical features include T-cell lymphoma, myeloid hyperplasia, and eosinophilia. The multilineage involvement in this disorder suggests transformation of a primitive stem cell. Abnormal karyotypes have been described in three such cases, including one case with t(8; I3)(p I I .2;q 12) and a second case with t(8; I 3)(p23;q 14). We report translocation of chromosomes 8 and I 3 in lymph node karyotypes from two patients with this syndrome. Fluorescence in situ hybridization confirmed an identical translocation, t(8; I 3)(p I I ;q I I -I2), in lymphoma cells from each patient. The translocation breakpoints are of particular interest because the FLJ3 receptor tyrosine kinase gene has been mapped to 13q 12. FLT3 is expressed highly in hematopoietic progenitor cells and in myeloid and lymphoid acute leukemias. Genes Chromosom Cancer 12: 148-15 I ( I 995);

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