✦ LIBER ✦

Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)

✍ Scribed by Roberta La Starza; Maurizio Trubia; Barbara Crescenzi; Caterina Matteucci; Massimo Negrini; Massimo F. Martelli; Pier Giuseppe Pelicci; Cristina Mecucci

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 123 KB
Volume: 36
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.10182

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✦ Synopsis

Abstract

The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE‐PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies. © 2003 Wiley‐Liss, Inc.

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The chromosome translocation t(7;11)(p15

The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9

✍ Takeshi Taketani; Tomohiko Taki; Ryoichi Ono; Yukio Kobayashi; Kohmei Ida; Yasuh 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB

The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part