Objective. To investigate the role of interleukin-6 (IL-6) and transforming growth factor pl (TGFp1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. Methods. Articular cartilage was obtained from human knee joints 24 hours after deat
Transforming growth factor β1 induction of Tissue Inhibitor of MetalloProteinases 3 in articular chondrocytes is mediated by reactive oxygen species
✍ Scribed by Wen Qing Li; Hamid Yaqoob Qureshi; Abdelhamid Liacini; Faramaze Dehnade; Muhammad Zafarullah
- Book ID
- 113629226
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 719 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0891-5849
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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,