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837 Transforming growth factor beta 1-induced hepatocyte apoptosis is mediated by SMAD3-dependent acute generation of reactive oxygen species

✍ Scribed by Dalliah Black; Suzanne Lyman; Ting Qian; John J. LeMasters; Richard Rippe; Kevin E. Behrns

Book ID
119530743
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
126 KB
Volume
38
Category
Article
ISSN
0270-9139

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## Abstract Transforming growth factor‐β1 (TGFβ1) is a multifunctional cytokine that is over expressed during liver hepatocytes injury and regeneration. SV40‐transformed CWSV‐1 rat hepatocytes that are p53‐defective undergo apoptosis in response to choline deficiency (CD) or TGFβ1, which mediates C