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156 TISSUE INHIBITOR OF METALLOPROTEINASES-3 INDUCTION BY TRANSFORMING GROWTH FACTOR BETA IN HUMAN CHONDROCYTES IS MEDIATED BY SMAD SIGNALING

✍ Scribed by H. Qureshi; G. Ricci; M. Zafarullah


Book ID
114350305
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
218 KB
Volume
15
Category
Article
ISSN
1063-4584

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TGF-Ξ²-induced expression of tissue inhib
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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,