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Transcriptional inhibition of connexin 43 BY EWS-FLI1: Implication in tumor development of ewing's sarcoma

✍ Scribed by J. Talbot⁎; G. Picarda; J. Amiaud; J. Chesneau; R. Brion; F. Tirode; D. Heymann; F. Redini; F. Verrecchia

Book ID
116325245
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
70 KB
Volume
50
Category
Article
ISSN
8756-3282

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✍ Howard A Chansky; Fariba Barahmand-pour; Qi Mei; Waqqar Kahn-Farooqi; Anna Zieli 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 881 KB

## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI‐1 chimeric fusion protein. The effect of EWS/FLI‐1 appears to be dominant negative since over‐expression of EWS does not overcome the sarcoma phenotype. Pr