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Inhibition of the transcriptional function of p53 by EWS–Fli1 chimeric protein in Ewing Family Tumors

✍ Scribed by Yan Li; Kazuhiro Tanaka; Xueli Fan; Fumihiko Nakatani; Xu Li; Tomoyuki Nakamura; Minoru Takasaki; Shunsaku Yamamoto; Yukihide Iwamoto

Book ID: 116335430
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 556 KB
Volume: 294
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2010.01.022

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## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI‐1 chimeric fusion protein. The effect of EWS/FLI‐1 appears to be dominant negative since over‐expression of EWS does not overcome the sarcoma phenotype. Pr