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Role of protein–protein interactions in the antiapoptotic function of EWS-Fli-1

✍ Scribed by Ramakrishnan, Ramugounder; Fujimura, Yasuo; Zou, Jian Ping; Liu, Fang; Lee, Leo; Rao, Veena N; Reddy, E Shyam P

Book ID
110068994
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
240 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract Ewing's Family Tumors (EFTs) most commonly harbor a specific t(11;22) translocation that generates the EWS/FLI1 fusion protein responsible for malignant transformation. Many potential downstream targets of EWS/FLI1 have been identified but a detailed mechanism by which the fusion protei