## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLIβ1 chimeric fusion protein. The effect of EWS/FLIβ1 appears to be dominant negative since overβexpression of EWS does not overcome the sarcoma phenotype. Pr
β¦ LIBER β¦
Differential regulation of the response to DNA damage in Ewing's sarcoma cells by ETS1 and EWS/FLI-1
β Scribed by Soldatenkov, Viatcheslav A; Trofimova, Irina N; Rouzaut, Ana; McDermott, Frank; Dritschilo, Anatoly; Notario, Vicente
- Book ID
- 110066589
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 198 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Despite recent improvements in multimodal therapies for osteosarcoma (OS) and Ewing's family of tumors (EFTs), the prognosis of relapsed cases remains very poor because of the resistance to chemotherapy. Histone deacetylase inhibitors (HDACIs), including members of the cyclic tetrapepti