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O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma

✍ Scribed by Bachmaier, R; Aryee, D N T; Jug, G; Kauer, M; Kreppel, M; Lee, K A; Kovar, H


Book ID
109970819
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
167 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI‐1 chimeric fusion protein. The effect of EWS/FLI‐1 appears to be dominant negative since over‐expression of EWS does not overcome the sarcoma phenotype. Pr