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TP53 mutations and Arg72Pro polymorphism in breast cancers

✍ Scribed by Evgeniy V. Denisov; Nadejda V. Cherdyntseva; Nicolay V. Litvyakov; Elena M. Slonimskaya; Elena A. Malinovskaya; Mikhail I. Voevoda; Valentina A. Belyavskaya; Vladimir N. Stegniy

Book ID
113513547
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
78 KB
Volume
192
Category
Article
ISSN
0165-4608

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## Abstract It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well‐known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actuall

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## Abstract No clear consensus has been reached on the __TP53__ Arg72Pro polymorphism (G12139C) and lung cancer risk. Thus, a meta‐analysis was conducted to summarize the possible association. There was no statistical association between 12139C (Pro allele) and lung cancer risk in Caucasians compar