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TP53Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis

✍ Scribed by De-Ke Jiang; Lei Yao; Wei-Hua Ren; Wen-Zhang Wang; Bo Peng; Long Yu

Book ID
107577214
Publisher
Springer US
Year
2010
Tongue
English
Weight
224 KB
Volume
28
Category
Article
ISSN
1357-0560

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## Abstract No clear consensus has been reached on the __TP53__ Arg72Pro polymorphism (G12139C) and lung cancer risk. Thus, a meta‐analysis was conducted to summarize the possible association. There was no statistical association between 12139C (Pro allele) and lung cancer risk in Caucasians compar

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## Abstract It is well known that the TP53 gene considerably influences on DNA repair processes. Polymorphisms in the TP53 gene, particularly the well‐known Arg72Pro in codon 72 of exon 4 (Ex4+119 G>C; rs1042522), can modify the functionality of the p53 protein and activation of DNA repair. Actuall