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Toward the total synthesis of pseudolaric acid B. Preparation of a key intermediate by degradation and its use in the reassembly of the natural product

✍ Scribed by Baogen Wu; Jean M. Karle; E.Blake Watkins; Mitchell A. Avery

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 135 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00596-8

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✦ Synopsis

Synthetic studies of pseudolaric acid B, 2, provided a relay synthesis of pseudolaric acid B (PLAB) via aldehyde 5. The aldehyde 5 can serve: to complete the total synthesis of PLAB; as a precursor for the synthesis of PLAB analogs; or as a substrate for the generation of radiolabeled PLAB for mechanistic studies.

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