First Desymmetrization of a Centrosymmet
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Joanne M. Holland; Mark Lewis; Adam Nelson
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Article
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2001
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John Wiley and Sons
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English
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Exploitation of molecular symmetry can greatly improve the efficiency of syntheses. The symmetry embedded in the centrosymmetric AB dioxepane fragment of hemibrevetoxin B was exploited for the first time in the preparation of an established intermediate in its total synthesis. Desymmetrization of th