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Chemical Predisposition in Synthesis: Application to the Preparation of the Pyrrolidine Natural Products, Plakoridines A and B.

โœ Scribed by Laura L. Etchells; Madeleine Helliwell; Neil M. Kershaw; Ali Sardarian; Roger C. Whitehead


Publisher
John Wiley and Sons
Year
2007
Weight
27 KB
Volume
38
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

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Exploitation of molecular symmetry can greatly improve the efficiency of syntheses. The symmetry embedded in the centrosymmetric AB dioxepane fragment of hemibrevetoxin B was exploited for the first time in the preparation of an established intermediate in its total synthesis. Desymmetrization of th