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Toward the total synthesis of hygrolidin: Stereocontrolled construction of the C1–C17 seco-acid fragment and the C18–C25 masked hemiacetal subunit

✍ Scribed by Kazuishi Makino; Ken-ichi Kimura; Noriyuki Nakajima; Shun-ichi Hashimoto; Osamu Yonemitsu

Book ID
104255923
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
265 KB
Volume
37
Category
Article
ISSN
0040-4039

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✦ Synopsis

Toward the first total synthesis of 16-membered macrolide antibiotic hygrolidin, the CI-CI 7 seco-acid fragment and the C18-C25 masked herniacetal subunit as potential precursors have been synthesized in enantiomericaUy homogeneous forms.

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