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Studies Directed toward the Total Synthesis of Azaspiracid: Stereoselective Construction of C 1 −C 12 , C 13 −C 19 , and C 21 −C 25 Fragments

✍ Scribed by Carter, Rich G.; Weldon, David J.


Book ID
126004120
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
69 KB
Volume
2
Category
Article
ISSN
1523-7060

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Studies directed toward the total synthe
✍ Rich G Carter; David E Graves 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 104 KB

The efficient entry to the C 1 -C 19 carbon backbone of azaspiracid is outlined utilizing a key Julia coupling strategy. Spirocyclization of a C 12 sulfone substrate induced formation of the unprecedented, nonnatural transoidal bisspiroketal. Construction of the bisspirocyclic array at C 10 and C 13