Total Synthesis of [α,γ-14C2]Uroporphyrin III
✍ Scribed by Prof. Dr. Burchard Franck; Dr. Dietrich Gantz; Dr. Fritz Hüper
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 226 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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## Abstract The syntheses of [γ‐^14^C]‐γ‐oxo‐2‐dibenzofuranbutanoic acid (furobufen) 7 and 2‐dibenzofuranacetic[carboxy‐^14^C] acid 3b, a major metabolite of furobufen, are described. A by‐product, the dialkylated malonate 6 obtained in the synthesis of 7, was isolated and characterized.
## Abstract 4‐|2‐(Dimethylamino)ethyl‐2‐^14^C| phenol (hordenine‐α‐^14^C) has been synthesised in three steps from |^14^C|potassium cyanide and __p__‐benzyloxybenzyl chloride which in turn was obtained in four steps from __p__‐hydroxybenzoic acid.
Both racemic [2-14C] juvenile hormone 111 (JH 111; methyl-l0,11-epoxy-3,7,11t rimethyl-2(E) , 6 ( E ) [2-14C]dodecadienoate) and its 2-(2) isomer were synthesised on a 1 millimolar scale by forming the 9,lO epoxide of geranyl acetone and reacting this with the anion of trimethylphosphon0-[2-~~C]acet