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Synthesis of racemic [2-14C] insect juvenile hormone III

✍ Scribed by Paul H. Adams

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
287 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

Both racemic [2-14C] juvenile hormone 111 (JH 111; methyl-l0,11-epoxy-3,7,11t rimethyl-2(E) , 6 ( E ) [2-14C]dodecadienoate) and its 2-(2) isomer were synthesised on a 1 millimolar scale by forming the 9,lO epoxide of geranyl acetone and reacting this with the anion of trimethylphosphon0-[2-~~C]acetate. purification the yield of [2-14C] JH 111 in the radiosynthetic step was 14%

(with purity >93% by GC, specific activity 0.4mCi/mmol) and 4.7% (>97%, 0.4mCiI mmol) for the 2-(2) isomer.

After

📜 SIMILAR VOLUMES

Radiochemical synthesis part II The prep
Radiochemical synthesis part II The preparation of 14C-labeled juvenile hormone
✍ W. Hafferl; R. Zurflüh; L. Dunham 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 423 KB 👁 1 views

dl-2-14C-Juvenile hormone was prepared from 2-1dC-trimethyl phosphonoacetate, sodium hydride and cis-9,iO-oxido-6-ethy~-iOmethy/dodec-5(t)-en-2-one in dry tetrahydrofuran and pur$ed by gas chromatography. The reaction conditions were established by synthesizing the trans-isomer of juvenile hormone.

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## Abstract The synthesis of [^14^C]‐10,11‐Epoxy‐(2E,6E)‐farnesyl diazoacetate in one vessel, starting from [^14^C]‐glyoxylic acid, is described. This compound is useful as a potential photoaffinity labeling agent for juvenile hormone binding sites.

Synthesis of 1-4′ -ethylphenoxy- 14C (U)
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## Abstract The preparation of 1‐4′ ethylphenoxy‐ ^14^C(U)‐6, 7‐ epoxy ‐ 3, 7‐dimthyl‐2‐octene (^1^, ^2^) involved a single reaction wherein 4‐ethlphenol‐^14^C(U) (^3^) was mixed with 1‐chloro‐6, 7‐epoxy‐3, 7‐dimithyl‐2‐octene in an acetone water solution at reflux lu‐sing potassium carbonate as a