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Total Synthesis of the Microtubule-Stabilizing Agent (−)-Laulimalide

✍ Scribed by Paterson, Ian; De Savi, Chris; Tudge, Matthew


Book ID
121213709
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
75 KB
Volume
3
Category
Article
ISSN
1523-7060

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Synthesis of (−)-laulimalide: an agent f
✍ David R. Williams; Liang Mi; Richard J. Mullins; Ryan E. Stites 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 131 KB

An enantioselective synthesis of (-)-laulimalide is described. Key reactions include a convergent allylation coupling reaction, asymmetric conjugate addition, the allenylstannane Ferrier reaction and a chelation-controlled alkenylzinc addition as the basis for stereocontrol in critical elements of c