Synthesis of (−)-laulimalide: an agent for microtubule stabilization

✍ Scribed by David R. Williams; Liang Mi; Richard J. Mullins; Ryan E. Stites

• Book ID: 104251325
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 131 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00907-3

✦ Synopsis

An enantioselective synthesis of (-)-laulimalide is described. Key reactions include a convergent allylation coupling reaction, asymmetric conjugate addition, the allenylstannane Ferrier reaction and a chelation-controlled alkenylzinc addition as the basis for stereocontrol in critical elements of chirality.