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Total Synthesis of Microtubule-Stabilizing Agent (−)-Laulimalide1

✍ Scribed by Ghosh, Arun K.; Wang, Yong; Kim, Joseph T.


Book ID
111898054
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
199 KB
Volume
66
Category
Article
ISSN
0022-3263

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Synthesis of (−)-laulimalide: an agent f
✍ David R. Williams; Liang Mi; Richard J. Mullins; Ryan E. Stites 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 131 KB

An enantioselective synthesis of (-)-laulimalide is described. Key reactions include a convergent allylation coupling reaction, asymmetric conjugate addition, the allenylstannane Ferrier reaction and a chelation-controlled alkenylzinc addition as the basis for stereocontrol in critical elements of c