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Total synthesis of the ionophore antibiotic X-206. Studies relevant to the stereoselective synthesis of the C(17)–C(26) synthon.

✍ Scribed by David A. Evans; Steven L. Bender

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
262 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereoselective synthesis of the keto-aldehyde 4, which embodies the structural features of the C(17)-C(26) section of the polyether X-206, is described.

Despite recent advances in asymmetric synthesis, the stereochemically complex polyether antibiotics remain as challenging targets for total synthesis. 1 Among the diverse members of this class of substances, X-2O62 merits special attention as a consequence of its general level of architectural complexity.

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